pH-responsive single-chain polymer nanoparticles utilising dynamic covalent enamine bonds

pH-responsive single-chain polymer nanoparticles utilising dynamic covalent enamine bonds.

Structurally dynamic single-chain polymer nanoparticles that can reversibly undergo a coil to particle transition via formation and cleavage of intramolecular dynamic enamine cross-links are reported.

Single-Chain Polymer Nanoparticles via Non-Covalent and Dynamic Covalent Bonds

The added-value behind reversible bonds is the possibility to develop responsive structurally dynamic materials which can adapt their constitution and, hence, properties to external stimuli. In recent years, much effort has been devoted to the design and synthesis of single-chain polymer nanoparticles (SCNPs) that can be reversibly assembled / disassembled in response to external environmental ...

Dynamic covalent single chain nanoparticles based on hetero Diels-Alder chemistry.

We introduce the fully reversible folding of single chain nanoparticles (SCNPs) based on covalent hetero Diels-Alder (HDA) chemistry. A cyclopentadiene (Cp)-protected cyanodithioester (CDTE) monomer is designed and copolymerized with methyl methacrylate (MMA) via RAFT polymerization. The polymer chains are folded and subsequently unfolded by exploiting the reversible nature of the HDA reaction.

Functional systems with orthogonal dynamic covalent bonds.

This review summarizes the use of orthogonal dynamic covalent bonds to build functional systems. Dynamic covalent bonds are unique because of their dual nature. They can be as labile as non-covalent interactions or as permanent as covalent bonds, depending on conditions. Examples from nature, reaching from the role of disulfides in protein folding to thioester exchange in polyketide biosynthesi...

Covalent Bonds